Chapter 2
Anticancer Drugs - A. Alkylating Agents
A classical alkylating agent works by
attaching an alkyl group or a small molecule to hinder/stop the replication of
DNA in cancer cells. Classic alkylating agents include nitrogen mustard, and
cyclophosphamide. Platinum drugs are a different type of alkylating agent.
Instead of directly attaching an alkyl group onto DNA, a platinum drug forms
coordination bonds with DNA and hampers the replication of DNA. Some examples
of alkylating agents are described below.
© Jiajiu Shaw, 2018
Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. All contents posted are extracted from the book, "SIDE EFFECTS OF CHEMOTHERAPY AND RADIOTHERAPY", prepared by Dr. Jiajiu Shaw, Dr. Frederick Valeriote, and Dr. Ben Chen.
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