A.1. Nitrogen mustards
One of the first alkylating agents
was nitrogen mustard, NH2 (Fig. 1.1). Nitrogen mustards are alkylating agents
but are not specific in their binding site. The utility of nitrogen mustards is
limited because they are very reactive and consequently very short lived.
Because of its excessive toxicity,
the original nitrogen mustard, NH2, is not often used nowadays. Instead, some
of its analogs or derivatives, such as cyclophosphamide, are being used.
© Jiajiu Shaw, 2018
Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. All contents posted are extracted from the book, "SIDE EFFECTS OF CHEMOTHERAPY AND RADIOTHERAPY", prepared by Dr. Jiajiu Shaw, Dr. Frederick Valeriote, and Dr. Ben Chen.
