Saturday, February 10, 2018

Additional Information and Other Common Questions (3)

Regular Testing and Early Detection

The second important strategy to fight against cancer is to do regular testing.  If anything on your body appears suspicious, it is much easier to deal with it in the early stage.  If you remember the analogy of taking care of the lawn, dealing with just a few dandelions in the early stage is much easier than dealing with a whole bunch of dandelions in the later stage.  This strategy works similarly in cancer treatment; early detection is the best way to start dealing with cancer.

Self-Examination

Self-awareness and self-examination are very important in cancer screening.  Let’s briefly use skin cancer as an example.  Skin cancers found and removed early are almost always curable.  Self-examination of the skin is not too difficult to perform except the back for that you may need someone else to help.  Basically, one should look carefully for any new or changing lesions that might be cancerous or precancerous. If you spot anything suspicious, see a doctor.  Self-examination should be done regularly; it is a small investment but it could be life-saving.

For other cancer such as breast cancer and testicular cancer, self-examination can also be very important.  Because different types of cancer require different techniques in self-examination, we won’t go into too many details.  It is suggested that you look up the self-examination procedure for individual cancers from other resources and consult with your physician. 

Cancer Screening by Professionals

As mentioned, early detection is a very important step in fighting against cancer.  If any cancer is detected early, it is much easier to treat.  I have several relatives diagnosed with cancer early enough and they are all doing well for over five years.

Indeed, cancer screening by medical professionals is very important.  However, one needs to keep in mind that some tests might create certain potential issues.  For example, some tests might give false-positive results, wherein the results indicate that cancer may be present but it is in fact not present.  Also, some test might show the false-negative results indicating cancer is not there although cancer is present.  Therefore, it is a good idea to have the screening done by a different method or by a second lab in order to be absolutely sure.  Sometimes, it may be necessary to do a biopsy for cancer screening.

New Cancer Diagnosis

One of the new methods in cancer diagnosis is the use of liquid biopsy.  Liquid biopsy is different from traditional biopsy wherein a tiny piece of living tissues is removed for diagnostic testing. Basically, in liquid biopsy, a small quantity of body fluid (blood, urine, etc.), instead of a tissue part, is taken for cancer diagnosis. 

Nowadays, the term, liquid biopsy, is becoming more popular in the field of cancer diagnosis and management.  Modern biotechnologies make it easier to detect more biomarkers more sensitively.    

For cancer liquid biopsies, the analyses are basically done on three categories: circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), and exosomes.  Detection of CTCs was first thought to be a useful tool many years ago but never became practical. In recent years, due to advanced biotechnologies, the analysis of ctDNA or exosomes is becoming more practical. Liquid biopsies make it easier for gene profiling and to identify which mutations are driving the growth of cancer. At the present time, some companies are already offering liquid biopsy tests for gene alterations to help cancer treatment.

What are the advantages of liquid biopsy as compared to conventional biopsy? For a conventional biopsy, a small piece of potential tumor tissue is taken; it could be painful and might not be a true representation of the molecular profile. On the other hand, liquid biopsy is non-invasive and less painful.  In addition, it could detect the heterogeneity of cancer. Therefore, it is easier to take a series of samples so that the tumor genomic can be monitored in a time course and easier to make adjustment in cancer treatment. Furthermore, liquid biopsies can be used as a potential screen for cancer.

Although liquid biopsy does not completely replace regular biopsy, it can be very useful in some cases, particularly in cancer diagnostics. For example, when a tumor is located at some site that is not easily accessible, regular biopsy could require more work and the patient may suffer significant pain.  In terms of early detection, liquid biopsy may be used to identify ctDNA to detect potential tumor that is not known or identified by other methods.


© Jiajiu Shaw, 2018

Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. All contents posted are extracted from the book I wrote, "IS CANCER IN US", published recently.