Showing posts with label Chemotherapy. Show all posts
Showing posts with label Chemotherapy. Show all posts

Saturday, February 19, 2022

Part III Management of the Side Effects of Chemotherapy and Radiotherapy

Part III

 

Chapter 1


How to Cope with the Side Effects 


Coping with the Side Effects

    Before, during, and after radiotherapy or chemotherapy, there are some prescription drugs and natural products that can be used to reduce specific side effects induced by the therapy. In addition, there are also some activities that patients can do to reduce the discomfort from cancer therapies. Let’s look at them according to the types of side effects.

Dealing with Type 1 Side Effects

    In general, patients should first consult their doctors to find out what medications are expected to work best for their situations. Other activities are described under individual side effects below.

Fever and Infection

Chemotherapy often lowers WBC count in the blood resulting in neutropenia. Because white blood cells are very important in fighting against infection, when a patient’s WBC count is lower than normal level, the patient is more susceptible to infection.

 

To reduce the chance of infection, patients should avoid going to public areas, such as theater and shopping mall. Also, avoid close contact with anyone who is ill. Wash hands frequently and when washing hands, use appropriate hand soap especially when the hands are visibly soiled.  In recent years, alcohol-based hand sanitizer is becoming popular and it can be very effective in reducing the number of germs. In addition, do not eat raw food including fish, beef, oyster, and food containing raw egg. Thoroughly wash the vegetables and fruits for salad. Wash the cutting board especially after cutting raw meat, poultry, or fish. A patients should call his doctors if the body temperature reaches 101 °F (or 38.3 °C) or higher.

 

Flu-Like Symptoms


After a chemotherapy treatment, some people may experience flu-like symptoms such as pains and muscle aches. If not serious, patients can take over-the-counter medications such as Tylenol or Advil to relieve the pain. However, if the symptom persists, patients should contact their doctors for prescription drugs. In many states and Washington D.C., marijuana may be prescribed by physicians for pain management.

 

Nausea and Vomiting

 

For the management of nausea, patients should try not to skip meals. An empty stomach can worsen the symptom. Eat small and light meals. Drink lots of fluids, such as water, tea, and juice. Acupressure is being used by some people to reduce nausea basically by pressing a specific acupressure point near the base of the arm.  There are special wristbands available for such an acupressure; the wristband usually has a knob to apply pressure to the correct spot.  Further, there are some anti-nausea over-the-counter drugs available to prevent and treat nausea and vomiting due to chemotherapy.

 

Fatigue


Fatigue is a common symptom for people treated for cancer. For some, the fatigue may last a long time after treatment, and it can discourage them from physical activity. However, proper exercise can actually help patients reduce fatigue. Physical therapy can also help patients maintain strength in the muscles, which could help fight the sense of depression that sometimes comes with physical fatigue.

 

Most cancer drugs can reduce the RBC count and may cause anemia, which can make patients feel tired easily. Most people have to make some adjustment in work and family responsibilities. For anemia patients, it’s a good idea to plan their major activities and try to maintain their regular daily activities as much as possible. The fatigue should gradually go away after the patients recover from chemotherapy.

 

Doing regular exercise such as yoga, taichi, and walking may be helpful in relaxation. If necessary, physicians can prescribe iron supplement or other newer drugs to boost the blood cells. These include Epogen (by Amgen), Neupogen (by Amgen), and Leukine (by Berlex), which function as colony-stimulating factors because of their ability to stimulate the formation of blood cells in the bone marrow. 

 

Appetite and Taste Changes


During chemotherapy, one may lose appetite and becomes more sensitive to odors. As a patient becomes healthier, his/her appetite will improve. Again, one should try to stay with healthful food (low fat, low calorie, and high fiber) and drink a lot of liquid. Also, it’s a good idea to avoid spicy food. For some people, eating too much spicy food can result in diarrhea.

 

With a loss of appetite, important nutrients may be lacking. Suitable dietary supplement products may be used to supply needed nutrition.

Menopause

Depending on a woman’s age and the type of chemotherapy administered, chemotherapy may temporarily stop the periods. As a result, one may experience symptoms such as hot flashes, decreased libido, vaginal dryness, mood changes, and sleeping disturbances. If a patient experiences any of these symptoms, she should call her doctor or nurse about suitable treatment for the symptoms. Meanwhile, consider eating soy products (such as soy milk and tofu) which may reduce hot flashes. Wear light cotton pajamas to help prevent overheating when sleeping. Use vaginal moisturizers or other water based lubricants as needed.

 

© Jiajiu Shaw, 2022

Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. All contents posted are extracted from the book, "SIDE EFFECTS OF CHEMOTHERAPY AND RADIOTHERAPY", prepared by Dr. Jiajiu Shaw, Dr. Frederick Valeriote, and Dr. Ben Chen. 

Thursday, December 30, 2021

Part III Management of the Side Effects of Chemotherapy and Radiotherapy

Part III

 

Chapter 1


How to Cope with the Side Effects 


Three Types of Side Effects

    In general, side effects from chemotherapy and radiotherapy can be divided into three types. The first is a set of physiological responses, which are acute and the least concerning, including appetite loss, nausea and vomiting, weakness and fatigue, as well as flu-like symptoms; all of these can be managed by specific actions.

Fig. 3.1  Common cell types in a cell renewal system 

The second type of side effects is more severe and may damage cells in renewal tissues. There are a number of such cell renewal tissues in the body encompassing the hematopoietic system, the gastrointestinal tract, skin, hair, gonads, and cornea. Fig. 3.1 shows the common cell types in a cell types in a cell renewal system. The first and basic cell type is the stem cell – destroy all of these and the tissue gradually disappears. These cells are especially sensitive to both radiation and chemotherapeutic agents, and more so when they are proliferating. If over 99.9% of the stem cells are destroyed, the renewal tissue can’t recover by itself and the host will die. If stem cells are not totally destroyed, stem cell transplant and some protective agents can ameliorate some of the damage. The “committed” stem cells and differentiating cells (which may require proliferation) are also sensitive to chemotherapy and radiotherapy since they are proliferating just like the cancer cells. Finally, the differentiated cells such as platelets and red blood cells are resistant to chemotherapy. However, since the differentiated cells have a specific half-life, they are “used up” and may not be replaced as the stem cells and differentiating precursor cells have been destroyed. 

The third type of side effects is direct damage to cells in major organs such as liver, heart, and brain. These are non-proliferating cells, and like the differentiated cells discussed above and relatively insensitive. However, some drugs do have selective toxicity to specific organs such as anthracyclines and cardiac toxicity.


© Jiajiu Shaw, 2021


Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. All contents posted are extracted from the book, "SIDE EFFECTS OF CHEMOTHERAPY AND RADIOTHERAPY", prepared by Dr. Jiajiu Shaw, Dr. Frederick Valeriote, and Dr. Ben Chen. 

Monday, December 20, 2021

Part III Management of the Side Effects of Chemotherapy and Radiotherapy

Part III

 

Chapter 1


How to Cope with the Side Effects 

The major side effects of chemotherapy and radiotherapy include tissue/organ injury which occasionally may be fatal. In addition, these side effects may prevent doctors from delivering the prescribed dose of therapy according to the predetermined schedule in the cancer treatment plan. It is important to understand that the expected outcome from therapy is based on delivering treatment at the dose and schedule according to the well-designed and predetermined treatment plan. In other words, not only are the side effects of chemotherapy or radiotherapy undesirable, they may also limit a patient’s ability to accept the complete therapeutic regimen (both dose and schedule) to achieve the best outcome.


© Jiajiu Shaw, 2021


Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. All contents posted are extracted from the book, "SIDE EFFECTS OF CHEMOTHERAPY AND RADIOTHERAPY", prepared by Dr. Jiajiu Shaw, Dr. Frederick Valeriote, and Dr. Ben Chen. 

Saturday, July 4, 2020

Chemotherapy and Its Side Effects: Chapter 3 - Side Effects of Chemotherapy


D. Other Side Effects

D.7. Ototoxicity

Ototoxicity is the toxicity on the function of the ear. It can be caused by a number of chemotherapy agents and antibiotics. The symptoms of ototoxicity include hearing loss, balance disorder, and ringing noise. Some anticancer drugs, such as cisplatin, can cause damage of hearing or even hearing loss.

© Jiajiu Shaw, 2020

Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. All contents posted are extracted from the book, "SIDE EFFECTS OF CHEMOTHERAPY AND RADIOTHERAPY", prepared by Dr. Jiajiu Shaw, Dr. Frederick Valeriote, and Dr. Ben Chen. 

Saturday, February 15, 2020

Chemotherapy and Its Side Effects: Chapter 3 - Side Effects of Chemotherapy

C. Intestine (also see mucositis)

Chemotherapy often causes diarrhea. Crypt epithelial cells on the lining of the small intestine reproduce almost as fast as the bone marrow cells. Therefore, crypt cells are often easily damaged by chemotherapy.


Epithelial cells derived from crypt cells actively secrete electrolytes and play an important role in the re-absorption of water secretion in the intestines. During a normal digestive process, suitable amount of water are secreted into the lumen of the small intestine as part of the digestion process; most of the water is reabsorbed afterwards. Damage of crypt cells by chemotherapy disturbs the normal water-absorption process in the intestine, thus causing diarrhea.


© Jiajiu Shaw, 2020

Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. All contents posted are extracted from the book, "SIDE EFFECTS OF CHEMOTHERAPY AND RADIOTHERAPY", prepared by Dr. Jiajiu Shaw, Dr. Frederick Valeriote, and Dr. Ben Chen.

Sunday, January 19, 2020

Chemotherapy and Its Side Effects: Chapter 3 - Side Effects of Chemotherapy

B. Hair

One of the most noticeable side effects of chemotherapy is hair loss. Remember that chemotherapy damages not only the fast-growing cancer cells but also the fast-growing normal cells? Because cells in the hair follicles are fast growing, they are more easily attacked by many cancer drugs, thus causing hair loss.


Hair loss caused by chemotherapy is often referred to as alopecia. Chemotherapy-induced alopecia is a significant problem in clinical oncology. Fortunately, the hair loss is usually not permanent and often the hair will begin to grow back several months after chemotherapy ends.

© Jiajiu Shaw, 2020

Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. All contents posted are extracted from the book, "SIDE EFFECTS OF CHEMOTHERAPY AND RADIOTHERAPY", prepared by Dr. Jiajiu Shaw, Dr. Frederick Valeriote, and Dr. Ben Chen.

Sunday, January 5, 2020

Chemotherapy and Its Side Effects: Chapter 3 - Side Effects of Chemotherapy

Part I
Chapter 3

Side Effects of Chemotherapy

      Chemotherapy can result in a wide range of side effects; many of them are due to its adverse activity on the fast-growing normal cells of the body such as bone marrow cells, hair follicle cells, and crypt epithelial cells on the small intestine lining. Other effects are due to its adverse activities on vital organs such as liver, kidney, and heart. Although the side effects induced by individual drugs can be different from drug to drug, they can be generalized and described below.

A.    Bone Marrow
Because most anticancer drugs tend to damage fast-growing bone marrow cells, which produce new blood cells, blood-related side effects are not unexpected as a result of chemotherapy. Basically, there are three major blood-related side effects resulted from bone marrow damage by chemotherapy; they are briefly described below:

A.1. Neutropenia

Neutropenia is defined as an abnormal decrease in the number of neutrophils, an abundant type of granular WBC that is highly destructive of microorganisms. A low WBC count may leave a patient vulnerable to bacterial infection and the chemotherapy regimen has to be put on hold until the WBC count is back to an acceptable level for the chemotherapy to resume. This is often a problem that interferes with the chemotherapy regimen.

A.2. Anemia

Anemia is defined as a deficiency of hemoglobin (Hb), which is an iron-containing protein that carries oxygen from the lungs to the body’s brains, muscles, tissues, and other organs; oxygen is critical to the health of tissues and organs. Symptoms of anemia include light headedness, tiredness, or dizziness when a patient stands up suddenly from a crouching position.

A.3. Thrombocytopenia

Thrombocytopenia refers to the condition of lower than normal platelet count. Platelets play a fundamental role in hemostasis (a complex process that causes the blood to clot and bleeding to stop) and are a natural source of growth factors including platelet-derived growth factor (PDGF), which plays a significant role in the repair and regeneration of connective tissues. A low platelet count may cause a person to experience bruising more easily or excessive bleeding. Patients with acute myeloid or lymphocytic leukemia often experience low platelet count. This is especially true when patients with acute leukemia are treated with chemotherapy

All of these three side effects are related to bone marrow damage and they can be diagnosed through the complete blood count (CBC) which represents the three types of cells in blood.


Currently, there are several drugs approved by the FDA to reduce individual side effects resulted from bone marrow damage. These drugs will be discussed later. In addition, some natural products have been claimed to have certain protective effects on bone marrow damage. However, one needs to look into the scientific evidence before making any conclusion or decision.

© Jiajiu Shaw, 2020

Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. All contents posted are extracted from the book, "SIDE EFFECTS OF CHEMOTHERAPY AND RADIOTHERAPY", prepared by Dr. Jiajiu Shaw, Dr. Frederick Valeriote, and Dr. Ben Chen.

Sunday, September 30, 2018

Status and Update of this Blog, September 30, 2018

Since this blog started on 9/7/2015, this blog has been viewed for 14,641 times by people around the world.

The first five countries are Israel (8,762), United States (2,796), Ireland (589), Russia (547), and Germany (546). The other viewers were from Ukraine, Brazil, United Kingdom, Japan, Spain, France, Cyprus,  Hong Kong, Canada, Italy, Thailand, Philippines, India, Malaysia, Mexico, Singapore, Chile, Argentina, Puerto Rico, Kenya, Brunel, etc. Isreal has moved up to the first place and United States of America has dropped to the second.

As to the browsers, 44% used Chrome, 29% used Firefox, 14% used Explorer, 8% used Safari, 1% used Opera, and the rest by all others. It is pretty clear that Chrome has been and is still the primary browser.

As to the operating systems, 44% used Windows, 18% used Linux, 14% used Android, 14% used Macintosh, and the rest by other systems. It is obvious that Windows is the most popular operating system.

One recent happening to share with you is that, as the principal investigator (PI), I have recently received another research grant from National Institutes of Health (NIH) of the United States to investigate a novel small molecule to reduce the side effects incurred by total body irradiation. The news release can be found on the website of 21st Century Therapeutics, www.21-cti.com.

By the way, if you’d like to read more than just my blog, you can order my second book (SIDE EFFECTS OF CHEMOTHERAPY AND RADIOTHERAPY) from amazon.com. Meanwhile, please continue to read my blog and recommend it to your loved ones and friends.


Thank you for our visit.

© Jiajiu Shaw, 2018

Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. All contents posted are extracted from the book, "SIDE EFFECTS OF CHEMOTHERAPY AND RADIOTHERAPY", prepared by Dr. Jiajiu Shaw, Dr. Frederick Valeriote, and Dr. Ben Chen. 

Saturday, September 8, 2018

Chemotherapy and Its Side Effects: Chapter 2 - Antimetabolites (Cont'd)

B.1. Methotrexate (also referred to as amethopterin)

Methotrexate has been used for treating cancer and autoimmune diseases for many years. Although it has been off-patent for many years, it is still very highly prescribed.

Methotrexate is an antimetabolite that interferes with the use of folic acid. As shown in Figure 1.6, the structures of methotrexate and folic acid are strikingly similar. Because folic acid is essential for the synthesis and repair of DNA, especially during cell growth and division, it is logical that methotrexate interferes with the growth of cancer cells.

Methotrexate is cytotoxic and has a wide range of potential side effects including myelosuppression and mucositis. Methotrexate is also highly teratogenic and should not be taken by women during pregnancy or expected to be pregnant. It is generally true that no chemotherapy is given for pregnant women and, for women of child-bearing age, precaution must be taken.



Fig. 1.6   Structures of methotrexate (left) and folic acid (right)



Sometimes, folic acid is used to reduce the side effects of methotrexate. However, folic acid could act as an antidote to methotrexate, therefore, it is better to use folic acid on the off days during methotrexate treatment.


© Jiajiu Shaw, 2018

Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. All contents posted are extracted from the book, "SIDE EFFECTS OF CHEMOTHERAPY AND RADIOTHERAPY", prepared by Dr. Jiajiu Shaw, Dr. Frederick Valeriote, and Dr. Ben Chen. 

Saturday, March 31, 2018

Chemotherapy and Its Side Effects: Chapter 1

Chapter 1
Introduction

     Mutation is not uncommon in our daily lives. Most mutated cells either keep their normal cellular functions or undergo a programmed cell death (apoptosis) and die at some point in time. In addition, many mutated cells are recognized and rapidly removed by the body’s immune system. Only a very small portion of mutated cells will evolve further and become cancerous cells with uncontrollable proliferation; this behavior is different from that of normal cells. For adult, most normal cells are well differentiated except for certain types of cells, such as epithelial cells and bone marrow hematopoietic progenitor cells, which are capable of continuous proliferation; unlike cancerous cells, the growth of normal cells is highly regulated and controlled.

Cancer is a group of various diseases in that some cells are mutated in certain ways so that they grow and divide continuously. Currently, there are more than 200 known cancers that afflict humans.

For the treatment of cancer, there are generally three conventional strategies: surgery, chemotherapy, and radiotherapy. In this book, we will focus on chemotherapy, radiotherapy, and their side effects.

Chemotherapy is a systemic treatment of cancer patients with one or more anticancer drugs (chemical agents) to kill cancer cells and/or slow down their growth. The name “chemotherapy” comes from chemical agents being used as a therapy for treating cancer. Chemotherapy plays a critical role in cancer treatment; it is estimated that more than half of all cancer patients receive chemotherapy.

Depending on the dosage form, cancer drugs may be administered through several different routes, including intravenous injection/infusion, oral (mouth) delivery, or a slow release dosage form embedded in a tissue by implantation. A chemotherapy regimen (a treatment plan including the dosing and schedule) usually includes the administration of at least one drug to fight cancer at a predetermined dose according to a suitable schedule, usually daily, weekly, or every several weeks. Due to the different characteristics of individual cancer drugs, the chemotherapy regimen for each drug may be different. Because cancer treatment is a delicate process, it is important to know that staying on the chemotherapy regimen gives a patient the optimal chance for a successful result.

Many times, additional supplementary drugs are used simultaneously in a chemotherapy regimen in order to achieve a better outcome to either increase the anticancer potency or reduce the side effects of chemotherapy; these drugs are often called adjuvant medications. Adjuvant drugs that are used to reduce the side effects of cancer therapy, including chemoprotective and radioprotective agents, will be discussed in Part III.

Most cancer drugs work by killing cancer cells or slowing down the growth of cancer cells. Unfortunately, most of the cancer drugs are not able to clearly distinguish between cancer cells and normal cells. Therefore, most cancer drugs will damage not only the fast-growing cancer cells but also the fast-growing normal cells, which include bone marrow cells, crypt epithelial cells (lining of small intestine), and hair follicles. In addition, a number of organs (e.g., liver, kidney, and heart) are often injured by chemotherapy.


In order to have a better understanding on how anticancer drugs work and what kind of side effects they can cause, let’s take a look at some anticancer drugs in different categories. 

© Jiajiu Shaw, 2018

Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. All contents posted are extracted from the book, "SIDE EFFECTS OF CHEMOTHERAPY AND RADIOTHERAPY", prepared by Dr. Jiajiu Shaw, Dr. Frederick Valeriote, and Dr. Ben Chen. 

Saturday, March 17, 2018

Side Effects of Chemotherapy and Radiotherapy: Preface

     Cancer is a group of diseases with similar characteristics, out-of-control growth of cancer cells. Conventional cancer treatments include surgery, chemotherapy, and radiotherapy. Although technology advancements have made vast improvements in the last two decades or so, there is no perfect treatment for cancer because of its complexity; one of the major issues related to cancer treatment is the unwanted side effects.

In the upcoming series, we will focus on the side effects induced by chemotherapy and radiotherapy. We will briefly introduce chemotherapy and radiotherapy; we will also describe the side effects, current methods to tackle the side effect issue, and how to manage the side effects.

The purpose of this coming series is to help people understand the potential side effects of chemotherapy and radiotherapy. However, it is important for you to know that this blog is not intended to substitute the expertise and judgment of your physicians or other medical practitioners.

Although the upcoming series related to side effects of chemotherapy and radiotherapy can be somewhat technical, people with some technical background in chemistry/biochemistry should be able to read through without much difficulty.

Finally, if this blog is useful for you in any way, please share it with your loved ones and friends.



Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. Most of the contents posted are extracted from the following books: (1) IS CANCER IN US, and (2) SIDE EFFECTS OF CHEMOTHERAPY AND RADIOTHERAPY. 

Sunday, March 4, 2018

Status of this blog as of March 4, 2018

As of March 4, 2018, this blog has been viewed for over 11,000 times by people around the world. The top three countries have changed a little bit. Instead of United States, Israel is now the new number one. The top ten regions are: Israel (6.683), United States (2,358), Germany (541), Russia, Ukraine, Brazil, Taiwan, Hong Kong, China, and France. Many people in other regions in the world also viewed this blog. Thank you for viewing my blog and I sincerely hope that you can learn something here.

In the near future, we will talk about a somewhat different topic: side effects of chemotherapy and radiotherapy. With the help from Dr. Frederick and Dr. Ben Chen, we published a book on this important subject, which is available at amazon. In the upcoming blogs, I will share with you most of the important contents of this book.

Furthermore, I plant to share with you my experience in fighting against my pancreatic tumor. My complete experience has been published as my 3rd book, HOW I FOUGHT AGAINST MY PANCREATIC TUMOR, published in March of 2017. If you don't have the book, you can look forward to seeing most of the contents here in this blog. Please be patient as I am just beginning to cover another important topic: Side Effects of Chemotherapy and Radiotherapy.

If you like what you read, please continue to read my blog and recommend it to your loved ones and friends. Thank you for your visiting.
  

Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. 

Saturday, September 24, 2016

Natural Products for Cancer Prevention/Management (2)

Glutathione

Glutathione is an important small-molecule antioxidant produced in all living beings, including human being.  Glutathione is found in almost all cells but most glutathione is found in the liver and plays an important role in liver detoxification.  It is directly involved in the neutralization of free radicals, reactive oxygen species, and heavy metals.  Some people consider it the most important antioxidant in the body.

As we mentioned before, antioxidants are important in protecting our cells and may slow down the aging process.  However, the protective effect of glutathione on normal cells might also work on cancer cells.  It has been reported that high levels of glutathione may help cancer cells become resistant to chemotherapy

© Jiajiu Shaw, 2016


Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. All contents posted are extracted from the book I am writing, "IS CANCER IN US", to be published in about two months.

Saturday, September 10, 2016

Methods of Cancer Treatment, Summary

Methods of Cancer Treatment - Summary

So far, we have discussed a number of cancer treatment methods, conventional and novel methods.  Each method has its own advantages and disadvantages.  Although significant progresses have been made in some of them in recent years, it seems like there is no perfect way to treat cancer at the present time.  Why? 

Remember that most cancer cells are mutated and transformed from normal/stem cells through problematic mutations; the problematic mutations could be only one out of many thousands of mutations.  Thus cancer cells are just like brothers/sisters of normal cells and similar in many ways.  This is what makes it so difficult to treat cancer.  In addition, any treatment that contravenes the growth of cancer cells might also affect normal cells, thus resulting in side effects.  Fortunately, modern technologies in surgery, chemotherapy, and radiotherapy have made significant progresses in reducing the side effects (i.e., injuries of normal cells).  

If there is a perfect way and it’s easy to deal with, we wouldn’t have many thousands of scientists in the world working day and night on finding better answers.  The way the world is created by nature, we are going to have a difficult time to find a perfect way to treat cancer.  However, researchers are making progress inch by inch; newer and better methods have been developed in the last 50 years or so and there will be more and more improvements discovered in the coming years to fight against cancer.

In my opinion, stem cell related therapies have the best chance to be among the best methods for treating cancer.  Among them, two strategies are most appealing to me; they are (1) potential treatment by exosomes, and (2) reversing cancer cells back to normal cells.  However, a lot of technical hurdles must be overcome before either can become practical.  In any case, I believe this is an exciting period of time for the research and development of cancer treatment. We are also putting some of our efforts in this general area and hope to make some contributions. 

Although there may not be a perfect therapy for cancer treatment at the present time, there are a few good ways to reduce the risk of getting cancer and/or to slow down cancer growth.  Other than the methods described previously, there are other aspects to consider in order to reduce the chances of getting cancer.  We will talk about these later. 

© Jiajiu Shaw, 2016

Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. Although some commercial products, publications, and services are mentioned in this blog, the author does not endorse any specific products, publications, or services.  None of the contents in this blog represents or warrants that any of the products, publications, or services is appropriate or effective for their intended purposes. Readers shall always seek the advice of their physicians or other medical practitioners with any questions regarding personal health or medical conditions and shall be solely responsible for their own decisions and/or actions.

Thursday, September 10, 2015

Chemotherapy

Because all drugs are essentially chemical materials, use of any drug as a cancer therapy is called chemotherapy.  Most cancer drugs tend to attack fast growing cells, which is one important characteristic of cancer cells.  However, some of the normal cells also have similar fast growing characteristic, including hair follicles, cells in the gastrointestinal tract, and skin, thus they have a high tendency to be attacked by cancer drugs.  This is the main reason why cancer patients often experience hair loss, diarrhea, and rashes during or after chemotherapy.

Generally speaking, chemotherapy drugs may be broadly divided into two basic categories based on their functions:

1. To inhibit or hamper DNA replication or RNA synthesis, thus, cell replication is inhibited or hampered.  
2. To affect cancer cell activities/behaviors and eventually result in cell death.  

© Jiajiu Shaw, 2015 

Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. All contents posted are extracted from the book I am writing, "IS CANCER IN US", to be published in about two months.