Showing posts with label Radiotherapy. Show all posts
Showing posts with label Radiotherapy. Show all posts

Saturday, February 19, 2022

Part III Management of the Side Effects of Chemotherapy and Radiotherapy

Part III

 

Chapter 1


How to Cope with the Side Effects 


Coping with the Side Effects

    Before, during, and after radiotherapy or chemotherapy, there are some prescription drugs and natural products that can be used to reduce specific side effects induced by the therapy. In addition, there are also some activities that patients can do to reduce the discomfort from cancer therapies. Let’s look at them according to the types of side effects.

Dealing with Type 1 Side Effects

    In general, patients should first consult their doctors to find out what medications are expected to work best for their situations. Other activities are described under individual side effects below.

Fever and Infection

Chemotherapy often lowers WBC count in the blood resulting in neutropenia. Because white blood cells are very important in fighting against infection, when a patient’s WBC count is lower than normal level, the patient is more susceptible to infection.

 

To reduce the chance of infection, patients should avoid going to public areas, such as theater and shopping mall. Also, avoid close contact with anyone who is ill. Wash hands frequently and when washing hands, use appropriate hand soap especially when the hands are visibly soiled.  In recent years, alcohol-based hand sanitizer is becoming popular and it can be very effective in reducing the number of germs. In addition, do not eat raw food including fish, beef, oyster, and food containing raw egg. Thoroughly wash the vegetables and fruits for salad. Wash the cutting board especially after cutting raw meat, poultry, or fish. A patients should call his doctors if the body temperature reaches 101 °F (or 38.3 °C) or higher.

 

Flu-Like Symptoms


After a chemotherapy treatment, some people may experience flu-like symptoms such as pains and muscle aches. If not serious, patients can take over-the-counter medications such as Tylenol or Advil to relieve the pain. However, if the symptom persists, patients should contact their doctors for prescription drugs. In many states and Washington D.C., marijuana may be prescribed by physicians for pain management.

 

Nausea and Vomiting

 

For the management of nausea, patients should try not to skip meals. An empty stomach can worsen the symptom. Eat small and light meals. Drink lots of fluids, such as water, tea, and juice. Acupressure is being used by some people to reduce nausea basically by pressing a specific acupressure point near the base of the arm.  There are special wristbands available for such an acupressure; the wristband usually has a knob to apply pressure to the correct spot.  Further, there are some anti-nausea over-the-counter drugs available to prevent and treat nausea and vomiting due to chemotherapy.

 

Fatigue


Fatigue is a common symptom for people treated for cancer. For some, the fatigue may last a long time after treatment, and it can discourage them from physical activity. However, proper exercise can actually help patients reduce fatigue. Physical therapy can also help patients maintain strength in the muscles, which could help fight the sense of depression that sometimes comes with physical fatigue.

 

Most cancer drugs can reduce the RBC count and may cause anemia, which can make patients feel tired easily. Most people have to make some adjustment in work and family responsibilities. For anemia patients, it’s a good idea to plan their major activities and try to maintain their regular daily activities as much as possible. The fatigue should gradually go away after the patients recover from chemotherapy.

 

Doing regular exercise such as yoga, taichi, and walking may be helpful in relaxation. If necessary, physicians can prescribe iron supplement or other newer drugs to boost the blood cells. These include Epogen (by Amgen), Neupogen (by Amgen), and Leukine (by Berlex), which function as colony-stimulating factors because of their ability to stimulate the formation of blood cells in the bone marrow. 

 

Appetite and Taste Changes


During chemotherapy, one may lose appetite and becomes more sensitive to odors. As a patient becomes healthier, his/her appetite will improve. Again, one should try to stay with healthful food (low fat, low calorie, and high fiber) and drink a lot of liquid. Also, it’s a good idea to avoid spicy food. For some people, eating too much spicy food can result in diarrhea.

 

With a loss of appetite, important nutrients may be lacking. Suitable dietary supplement products may be used to supply needed nutrition.

Menopause

Depending on a woman’s age and the type of chemotherapy administered, chemotherapy may temporarily stop the periods. As a result, one may experience symptoms such as hot flashes, decreased libido, vaginal dryness, mood changes, and sleeping disturbances. If a patient experiences any of these symptoms, she should call her doctor or nurse about suitable treatment for the symptoms. Meanwhile, consider eating soy products (such as soy milk and tofu) which may reduce hot flashes. Wear light cotton pajamas to help prevent overheating when sleeping. Use vaginal moisturizers or other water based lubricants as needed.

 

© Jiajiu Shaw, 2022

Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. All contents posted are extracted from the book, "SIDE EFFECTS OF CHEMOTHERAPY AND RADIOTHERAPY", prepared by Dr. Jiajiu Shaw, Dr. Frederick Valeriote, and Dr. Ben Chen. 

Thursday, December 30, 2021

Part III Management of the Side Effects of Chemotherapy and Radiotherapy

Part III

 

Chapter 1


How to Cope with the Side Effects 


Three Types of Side Effects

    In general, side effects from chemotherapy and radiotherapy can be divided into three types. The first is a set of physiological responses, which are acute and the least concerning, including appetite loss, nausea and vomiting, weakness and fatigue, as well as flu-like symptoms; all of these can be managed by specific actions.

Fig. 3.1  Common cell types in a cell renewal system 

The second type of side effects is more severe and may damage cells in renewal tissues. There are a number of such cell renewal tissues in the body encompassing the hematopoietic system, the gastrointestinal tract, skin, hair, gonads, and cornea. Fig. 3.1 shows the common cell types in a cell types in a cell renewal system. The first and basic cell type is the stem cell – destroy all of these and the tissue gradually disappears. These cells are especially sensitive to both radiation and chemotherapeutic agents, and more so when they are proliferating. If over 99.9% of the stem cells are destroyed, the renewal tissue can’t recover by itself and the host will die. If stem cells are not totally destroyed, stem cell transplant and some protective agents can ameliorate some of the damage. The “committed” stem cells and differentiating cells (which may require proliferation) are also sensitive to chemotherapy and radiotherapy since they are proliferating just like the cancer cells. Finally, the differentiated cells such as platelets and red blood cells are resistant to chemotherapy. However, since the differentiated cells have a specific half-life, they are “used up” and may not be replaced as the stem cells and differentiating precursor cells have been destroyed. 

The third type of side effects is direct damage to cells in major organs such as liver, heart, and brain. These are non-proliferating cells, and like the differentiated cells discussed above and relatively insensitive. However, some drugs do have selective toxicity to specific organs such as anthracyclines and cardiac toxicity.


© Jiajiu Shaw, 2021


Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. All contents posted are extracted from the book, "SIDE EFFECTS OF CHEMOTHERAPY AND RADIOTHERAPY", prepared by Dr. Jiajiu Shaw, Dr. Frederick Valeriote, and Dr. Ben Chen. 

Monday, December 20, 2021

Part III Management of the Side Effects of Chemotherapy and Radiotherapy

Part III

 

Chapter 1


How to Cope with the Side Effects 

The major side effects of chemotherapy and radiotherapy include tissue/organ injury which occasionally may be fatal. In addition, these side effects may prevent doctors from delivering the prescribed dose of therapy according to the predetermined schedule in the cancer treatment plan. It is important to understand that the expected outcome from therapy is based on delivering treatment at the dose and schedule according to the well-designed and predetermined treatment plan. In other words, not only are the side effects of chemotherapy or radiotherapy undesirable, they may also limit a patient’s ability to accept the complete therapeutic regimen (both dose and schedule) to achieve the best outcome.


© Jiajiu Shaw, 2021


Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. All contents posted are extracted from the book, "SIDE EFFECTS OF CHEMOTHERAPY AND RADIOTHERAPY", prepared by Dr. Jiajiu Shaw, Dr. Frederick Valeriote, and Dr. Ben Chen. 

Saturday, November 27, 2021

Radiotherapy and Its Side Effects: Chapter 3 - Modern Technologies in Radiotherapy

PART II

Chapter 3

Modern Technologies in Radiotherapy (Cont'd)


4. Improvement of radiotherapy by using radiomitigators

Different from radioprotectors, which need to be administered either before or during radiotherapy, radiomitigators can be administered after radiation treatment. Radiomitigation can also be very useful in term of national defense with the increasing global threat of terrorists, such as potential radiological attack by dirty bombs.

Currently, there is not an FDA approved radiomitigator. However, there are a number of drug candidates under investigation as radiomitigator.


 © Jiajiu Shaw, 2021


Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. All contents posted are extracted from the book, "SIDE EFFECTS OF CHEMOTHERAPY AND RADIOTHERAPY", prepared by Dr. Jiajiu Shaw, Dr. Frederick Valeriote, and Dr. Ben Chen. 

Monday, November 15, 2021

Radiotherapy and Its Side Effects: Chapter 3 - Modern Technologies in Radiotherapy

PART II

Chapter 3

Modern Technologies in Radiotherapy (Cont'd)


Special Announcement related to this topic, radioprotectors.

We have just been allowed a patent by the US Patent and Trademark Office (US PTO). This patent is related to a new radioprotector. Further details will be announced after this patent is officially issued in the near future.

 

Saturday, November 6, 2021

Radiotherapy and Its Side Effects: Chapter 3 - Modern Technologies in Radiotherapy

 PART II

Chapter 3

Modern Technologies in Radiotherapy (Cont'd)


3. Improvement of radiotherapy by using radioprotectors 

Radioprotection is another important approach in radiotherapy. Basically, a therapeutic agent, radioprotector, is administered to a patient before the patient is treated by radiotherapy. In other words, radioprotectors protect normal tissues against radiation-induced side effects. Ideally, radioprotectors produce or stimulate certain biological reactions/products which then counteract the adverse effects caused by radiation. 

Unfortunately, there has not been any significantly improved radioprotector since the discovery and approval of a popular broad-spectrum radioprotective drug, amifostine (Fig. 2.3), by the FDA. Interestingly, amifostine was originally approved to reduce the cumulative renal toxicity associated with repeated administration of cisplatin in patients with advanced ovarian cancer and non-small cell lung cancer. However, while nephroprotection was observed, amifostine also formed chelation with cisplatin and reduced its anticancer activity. Therefore, its indication for chemoprotection in cisplatin treatment in non-small cell lung cancer was withdrawn in 2005.

Fig. 2.3.   Structure of amifostine (WR2721) and its metabolite

 

 More details about amifostine and other radioprotectors are described in Part III.


© Jiajiu Shaw, 2021


Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. All contents posted are extracted from the book, "SIDE EFFECTS OF CHEMOTHERAPY AND RADIOTHERAPY", prepared by Dr. Jiajiu Shaw, Dr. Frederick Valeriote, and Dr. Ben Chen. 

Saturday, October 16, 2021

Radiotherapy and Its Side Effects: Chapter 3 - Modern Technologies in Radiotherapy

 PART II

Chapter 3

Modern Technologies in Radiotherapy (Cont'd)

2. Improvement of radiotherapy by using radiosensitizers

A radiosensitizer (also referred to as a radiosensitizing agent) is a pharmaceutical agent that makes tumor cells more sensitive to radiation, thus, increasing the efficiency of radiotherapy. For example, oxygen is known to increase tumor sensitivity to radiation by forming free radicals that can damage DNA. 

As a solid tumor continues to grow, some cancer cells outgrow their blood supply and become sufficiently removed from their capillaries to become hypoxic (lack of oxygen). As a result, cancer cells survive by another mechanism called glycolysis. Glycolysis is a process in which glucose is converted into pyruvate by an oxygen-independent metabolic pathway; the process produces energy which is then stored in the form of ATP (adenosine triphosphate) for anaerobic cancer cells. In the presence of oxygen, ATP is formed through oxidative phosphorylation. 

The process of glycolysis further results in excess lactic acid, which makes solid tumor more acidic (pH can be as low as 6.2). In general, cancer cells under acidic condition (mainly due to hypoxia) are more resistant to killing by radiotherapy and some cancer drugs. 

      Currently, there are a number of agents being investigated as potential radiosensitizers. Some examples of radiosensitizers are shown in Part III. 


© Jiajiu Shaw, 2021

Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. All contents posted are extracted from the book, "SIDE EFFECTS OF CHEMOTHERAPY AND RADIOTHERAPY", prepared by Dr. Jiajiu Shaw, Dr. Frederick Valeriote, and Dr. Ben Chen. 


Saturday, August 21, 2021

Radiotherapy and Its Side Effects: Chapter 3 - Modern Technologies in Radiotherapy

 PART II

Chapter 3

Modern Technologies in Radiotherapy (Cont'd)

1. Improvements on the technical aspects of radiotherapy 

Generally, radiation oncologists attempt to reduce the injury to normal tissues surrounding the target tumor by limiting (or blocking) the radiation field. In recent years, a number of significant technical developments and modifications in radiotherapy have been developed in order to increase the efficacy of radiotherapy and/or reduce radiotherapy-induced injury. These technology improvements include using multiple ports, higher radiation doses, interstitial brachytherapy, stereotactic radiosurgery, and TomoTherapy. In general, therapists use these approaches in attempts to increase the radiation dose to the tumor tissue while decreasing the dose to the surrounding normal tissue(s). The main goals are to enhance/maintain the therapeutic effect while minimizing the damages to normal tissues. 

A representative example of these newer technologies is stereotactic radiotherapy. Stereotactic radiotherapy utilizes small fractions of high-dose radiation (as compared to conventional dose) from different angles to destroy tumor tissue. By giving multiple radiation doses from different angles, it can improve the radiotherapy outcome while minimizing potential side effects on normal tissues, especially the skin. Stereotactic radiotherapy is now frequently used to treat brain tumors and other types of solid tumors. 

A specific form of stereotactic radiotherapy used for brain tumors is called stereotactic surgery, which utilizes high dose radiation (x-ray or gamma ray) to precisely focus on the specific area in the brain to destroy tumor tissues in the brain, very similar to surgery, thus often referred to as radiation surgery. In this treatment, the dose and the treatment area have to be precisely coordinated to ensure that normal tissues in the proximity suffer the least damage by the high dose radiation. It is also called fractionated stereotactic radiosurgery wherein the total dose of radiation is divided into several doses and delivered in several days. 

Another popular new technology is called TomoTherapy. It is a computed tomograph (CT)-guided intensity modulated radiation therapy (IMRT) that delivers radiation to the tumor slice-by-slice, which is different from other forms of external beam radiation therapy in which the entire tumor volume is irradiated. TomoTherapy is essentially an image-guided radiation therapy (IGRT). The “beam on” time for TomoTherapy (3 to 5 minutes) is similar to normal radiotherapy. However, it does require additional daily CT to precisely locate the tumor because tumor size and position may shift due to the shrinkage over time. The daily CT will help the operator in directing the radiation beam to modify the treatment (adaptive radiotherapy). TomoTherapy has been used in many solid tumors including prostate cancer, lung cancer, as well as head and neck cancer. 

In recent years, stereotactic radiotherapy is being combined with TomoTherapy. Right before the radiotherapy procedure, a patient is positioned on an examination table and a high-resolution CT scan is used to determine the precise location, size, and shape of the tumor. The data is then transferred to the computing system wherein an exact treatment plan is defined in real time. Once the patient is positioned, the radiation source is rotated and/or orientated by a computer to different positions/angles, and a predetermined dose of radiation is targeted at the tumor while sparing the healthy tissues. Commercially, several advanced radiotherapy systems utilizing similar principle have been developed and used. Examples of modern radiotherapy systems include Discovery CT590 RT and Optima CT580 made by GE Healthcare, and CyberKnife® made by Accuray. The most recent comprehensive radiosurgery system, Edge™, is made by Varian Medical Systems.  Edge™ is just entering the market and there are only few units installed in the United States. It is a dedicated system for performing advanced radiosurgery using new real-time tumor tracking technology.


© Jiajiu Shaw, 2021

Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. All contents posted are extracted from the book, "SIDE EFFECTS OF CHEMOTHERAPY AND RADIOTHERAPY", prepared by Dr. Jiajiu Shaw, Dr. Frederick Valeriote, and Dr. Ben Chen. 

Saturday, July 24, 2021

Radiotherapy and Its Side Effects: Chapter 3 - Modern Technologies in Radiotherapy

 PART II

Chapter 3

Modern Technologies in Radiotherapy


     Many approaches have been employed by the medical/pharmaceutical community to enhance the therapeutic effect of radiotherapy and/or to protect normal tissues or ameliorate tissue injury induced by radiotherapy. In general, there are four major approaches: (1) improvements/modifications on technical aspects of radiotherapy, (2) use of radiosensitizers to enhance the killing of radio-resistant cancer cells, (3) use of radioprotective agents to protect normal tissues and/or reduce the side effects, and (4) use of radiomitigators to speed up the recovery of normal tissues from injury induced by radiotherapy.




© Jiajiu Shaw, 2021

Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. All contents posted are extracted from the book, "SIDE EFFECTS OF CHEMOTHERAPY AND RADIOTHERAPY", prepared by Dr. Jiajiu Shaw, Dr. Frederick Valeriote, and Dr. Ben Chen. 

Saturday, June 5, 2021

Radiotherapy and Its Side Effects: Chapter 2 - Side Effects of Radiotherapy

PART II
Chapter 2
Side Effects of Radiotherapy (Cont'd)

Additional information about the side effects of radiotherapy

Because a human body is a delicate and complicated biological system, and the inter-communication among different organs are even more complex, some side effects are inter-connected and may not be clearly separated from one another. Let’s use some examples for further illustration.

Cancer patients treated by high dose radiation onto specific organ may suffer organ damages in addition to other side effects (hair loss, diarrhea, etc.). Let’s look at the radiotherapy on liver cancer as a specific example. Patients with liver cancer, when treated by ionizing radiation, may suffer from liver damage and/or liver function reduction.

There are several reasons why organ damages occur after radiation therapy. The obvious reason is that liver cells damaged by DNA will result in the damage of liver tissue through mechanisms such as programmed cell death (apoptosis). The other important reason is that certain cytokines, such as TNF-a, in liver and blood are often markedly induced by radiation therapy. As described before, abnormally elevated levels of TNF-a will kill the surrounding cells (no matter cancer cells or normal cells), and will cause certain liver damage. 

Our experimental results showed that radiation in mouse liver induced liver damage (reflected by elevated serum levels of both aspartate transaminase (AST) and alanine transaminase (ALT), and the liver damage is in correlation with increased levels for serum TNF-a induced by irradiation. Pre-treatment of mice with a small-molecule TNF-a modulator UTL-5d (Fig. 2.2) effectively reduced TNF-a secretion and resulted in marked reduction of ALT/AST levels. This implies that TNF-a may play an important role in damaging the liver and UTL-5d compound may be a potential agent for radioprotection.

                                                                    Fig. 2.2   Structure of UTL-5d

    In order to reduce the side effects induced by radiotherapy, there are several general strategies being employed as described in the next chapter. 


© Jiajiu Shaw, 2021

Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. All contents posted are extracted from the book, "SIDE EFFECTS OF CHEMOTHERAPY AND RADIOTHERAPY", prepared by Dr. Jiajiu Shaw, Dr. Frederick Valeriote, and Dr. Ben Chen. 


Friday, March 26, 2021

Radiotherapy and Its Side Effects: Chapter 2 - Side Effects of Radiotherapy

PART II
Chapter 2
Side Effects of Radiotherapy (Cont'd)

3. Activation of immunologic responses

    In addition to producing the direct DNA damage, radiation can also produce a lot of free radicals, including reactive oxygen species (ROS), and cause indirect damages to normal tissues/organs.  The delicate immune system can also be disturbed by this oxidative stress, causing extraordinary number of immunological responses, including the abnormal release of many cytokines.

    Cytokines are regulatory proteins released by cells of the immune system. It has been reported that a number of cytokines may be induced by radiation, including tumor necrosis factor alpha (TNF-α), IL-1, IL-4, IL-5, IL-6, IL-8, IL-10, and transforming growth factor beta (TGF-β).  The alteration of cytokine levels in blood, skin, or other tissues can cause a number of pharmacological responses. 


© Jiajiu Shaw, 2021

Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. All contents posted are extracted from the book, "SIDE EFFECTS OF CHEMOTHERAPY AND RADIOTHERAPY", prepared by Dr. Jiajiu Shaw, Dr. Frederick Valeriote, and Dr. Ben Chen. 



Sunday, January 31, 2021

Radiotherapy and Its Side Effects: Chapter 2 - Side Effects of Radiotherapy

PART II
Chapter 2
Side Effects of Radiotherapy (Cont'd)


1.       Damage to the DNA of normal cells 

 The potential adverse effects of radiotherapy to the DNA of normal cells may result in tissue/organ damage and potentially secondary cancer. This is mainly due to (1) the direct exposure of normal cells to radiation, and (2) the indirect effect from the free radicals generated by radiation, which might result in the modification of certain genes generally referred to mutation. As a result, there is a possibility that certain cancer might be induced in the future, also known as secondary cancer, especially if high radiation dose is used often. 

In recent years, significant technical improvements have been made to greatly reduce this type of potential side effect. Examples of the newer radiotherapy technologies are described in the following chapter.


© Jiajiu Shaw, 2021

Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. All contents posted are extracted from the book, "SIDE EFFECTS OF CHEMOTHERAPY AND RADIOTHERAPY", prepared by Dr. Jiajiu Shaw, Dr. Frederick Valeriote, and Dr. Ben Chen. 

Saturday, December 26, 2020

Radiotherapy and Its Side Effects: Chapter 2 - Side Effects of Radiotherapy

PART II
Chapter 2
Side Effects of Radiotherapy

Although radiotherapy is a major and often effective modality in treating cancer patients, it can inflict serious damage on healthy tissues/organs. Because radiotherapy utilizes high energy radiation to kill cancer cells, injury to normal organ is almost inevitable. For example, the acute side effects of radiotherapy can occur on any surrounding normal tissues be it skin, brain or lung.

     Fortunately, many of the side effects caused by radiotherapy are reversible, but some may not become apparent until months or even years later, such as secondary tumor formation. Fortunately, modern technologies in radiotherapy can significantly reduce the radiation exposure of normal tissues and reduce the side effects thereof.

In general, the side effects of radiotherapy can be summarized in the following four categories:

          1. Damage to the DNA of normal cells
2. Damage to cell renewal
3. Activation of immunologic responses
4.  Other side effects of radiotherapy




© Jiajiu Shaw, 2020

Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. All contents posted are extracted from the book, "SIDE EFFECTS OF CHEMOTHERAPY AND RADIOTHERAPY", prepared by Dr. Jiajiu Shaw, Dr. Frederick Valeriote, and Dr. Ben Chen. 

Saturday, July 18, 2020

Radiotherapy and Its Side Effects: Chapter 1 - Introduction

PART II
Chapter 1
Introduction

Radiotherapy is also referred to as radiation therapy.  Radiotherapy deals with the treatment of cancer and it should not be confused with radiology, which deals with the study and application of radiation as a diagnostic tool.

Radiotherapy is a method of treating cancer patients by using ionizing radiation, which consists of either subatomic particles or electromagnetic waves that are energetic enough to knock off electrons from atoms or molecules to ionize them. Ionizing radiation comes from two sources shown below:

(1) Radiation is emitted by radioactive substances including cobalt, cesium, radium, uranium, radon, and plutonium;
(2) Radiation is produced by medical devices such as an x-ray machine.

Examples of ionizing particles include a particles, b particles (electrons), protons, and neutrons; examples of electromagnetic waves include x-ray, gamma ray, and ultraviolet (UV).


      Radiotherapy can be used to treat almost every type of solid tumor locally, including cancers of the breast, brain, lung, liver, cervix, pancreas, prostate, skin, stomach, and uterus. It can also be used to treat leukemia (cancer of blood-forming cells) and lymphoma (cancer of the lymphatic system, which is an important part of the immune system). In some cases, patients may receive a total body irradiation (TBI) for certain cancer, such as acute leukemia, as a pivotal part of bone marrow transplantation.



© Jiajiu Shaw, 2020

Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. All contents posted are extracted from the book, "SIDE EFFECTS OF CHEMOTHERAPY AND RADIOTHERAPY", prepared by Dr. Jiajiu Shaw, Dr. Frederick Valeriote, and Dr. Ben Chen. 

Sunday, September 30, 2018

Status and Update of this Blog, September 30, 2018

Since this blog started on 9/7/2015, this blog has been viewed for 14,641 times by people around the world.

The first five countries are Israel (8,762), United States (2,796), Ireland (589), Russia (547), and Germany (546). The other viewers were from Ukraine, Brazil, United Kingdom, Japan, Spain, France, Cyprus,  Hong Kong, Canada, Italy, Thailand, Philippines, India, Malaysia, Mexico, Singapore, Chile, Argentina, Puerto Rico, Kenya, Brunel, etc. Isreal has moved up to the first place and United States of America has dropped to the second.

As to the browsers, 44% used Chrome, 29% used Firefox, 14% used Explorer, 8% used Safari, 1% used Opera, and the rest by all others. It is pretty clear that Chrome has been and is still the primary browser.

As to the operating systems, 44% used Windows, 18% used Linux, 14% used Android, 14% used Macintosh, and the rest by other systems. It is obvious that Windows is the most popular operating system.

One recent happening to share with you is that, as the principal investigator (PI), I have recently received another research grant from National Institutes of Health (NIH) of the United States to investigate a novel small molecule to reduce the side effects incurred by total body irradiation. The news release can be found on the website of 21st Century Therapeutics, www.21-cti.com.

By the way, if you’d like to read more than just my blog, you can order my second book (SIDE EFFECTS OF CHEMOTHERAPY AND RADIOTHERAPY) from amazon.com. Meanwhile, please continue to read my blog and recommend it to your loved ones and friends.


Thank you for our visit.

© Jiajiu Shaw, 2018

Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. All contents posted are extracted from the book, "SIDE EFFECTS OF CHEMOTHERAPY AND RADIOTHERAPY", prepared by Dr. Jiajiu Shaw, Dr. Frederick Valeriote, and Dr. Ben Chen. 

Saturday, March 31, 2018

Chemotherapy and Its Side Effects: Chapter 1

Chapter 1
Introduction

     Mutation is not uncommon in our daily lives. Most mutated cells either keep their normal cellular functions or undergo a programmed cell death (apoptosis) and die at some point in time. In addition, many mutated cells are recognized and rapidly removed by the body’s immune system. Only a very small portion of mutated cells will evolve further and become cancerous cells with uncontrollable proliferation; this behavior is different from that of normal cells. For adult, most normal cells are well differentiated except for certain types of cells, such as epithelial cells and bone marrow hematopoietic progenitor cells, which are capable of continuous proliferation; unlike cancerous cells, the growth of normal cells is highly regulated and controlled.

Cancer is a group of various diseases in that some cells are mutated in certain ways so that they grow and divide continuously. Currently, there are more than 200 known cancers that afflict humans.

For the treatment of cancer, there are generally three conventional strategies: surgery, chemotherapy, and radiotherapy. In this book, we will focus on chemotherapy, radiotherapy, and their side effects.

Chemotherapy is a systemic treatment of cancer patients with one or more anticancer drugs (chemical agents) to kill cancer cells and/or slow down their growth. The name “chemotherapy” comes from chemical agents being used as a therapy for treating cancer. Chemotherapy plays a critical role in cancer treatment; it is estimated that more than half of all cancer patients receive chemotherapy.

Depending on the dosage form, cancer drugs may be administered through several different routes, including intravenous injection/infusion, oral (mouth) delivery, or a slow release dosage form embedded in a tissue by implantation. A chemotherapy regimen (a treatment plan including the dosing and schedule) usually includes the administration of at least one drug to fight cancer at a predetermined dose according to a suitable schedule, usually daily, weekly, or every several weeks. Due to the different characteristics of individual cancer drugs, the chemotherapy regimen for each drug may be different. Because cancer treatment is a delicate process, it is important to know that staying on the chemotherapy regimen gives a patient the optimal chance for a successful result.

Many times, additional supplementary drugs are used simultaneously in a chemotherapy regimen in order to achieve a better outcome to either increase the anticancer potency or reduce the side effects of chemotherapy; these drugs are often called adjuvant medications. Adjuvant drugs that are used to reduce the side effects of cancer therapy, including chemoprotective and radioprotective agents, will be discussed in Part III.

Most cancer drugs work by killing cancer cells or slowing down the growth of cancer cells. Unfortunately, most of the cancer drugs are not able to clearly distinguish between cancer cells and normal cells. Therefore, most cancer drugs will damage not only the fast-growing cancer cells but also the fast-growing normal cells, which include bone marrow cells, crypt epithelial cells (lining of small intestine), and hair follicles. In addition, a number of organs (e.g., liver, kidney, and heart) are often injured by chemotherapy.


In order to have a better understanding on how anticancer drugs work and what kind of side effects they can cause, let’s take a look at some anticancer drugs in different categories. 

© Jiajiu Shaw, 2018

Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. All contents posted are extracted from the book, "SIDE EFFECTS OF CHEMOTHERAPY AND RADIOTHERAPY", prepared by Dr. Jiajiu Shaw, Dr. Frederick Valeriote, and Dr. Ben Chen. 

Sunday, March 4, 2018

Status of this blog as of March 4, 2018

As of March 4, 2018, this blog has been viewed for over 11,000 times by people around the world. The top three countries have changed a little bit. Instead of United States, Israel is now the new number one. The top ten regions are: Israel (6.683), United States (2,358), Germany (541), Russia, Ukraine, Brazil, Taiwan, Hong Kong, China, and France. Many people in other regions in the world also viewed this blog. Thank you for viewing my blog and I sincerely hope that you can learn something here.

In the near future, we will talk about a somewhat different topic: side effects of chemotherapy and radiotherapy. With the help from Dr. Frederick and Dr. Ben Chen, we published a book on this important subject, which is available at amazon. In the upcoming blogs, I will share with you most of the important contents of this book.

Furthermore, I plant to share with you my experience in fighting against my pancreatic tumor. My complete experience has been published as my 3rd book, HOW I FOUGHT AGAINST MY PANCREATIC TUMOR, published in March of 2017. If you don't have the book, you can look forward to seeing most of the contents here in this blog. Please be patient as I am just beginning to cover another important topic: Side Effects of Chemotherapy and Radiotherapy.

If you like what you read, please continue to read my blog and recommend it to your loved ones and friends. Thank you for your visiting.
  

Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. 

Saturday, September 10, 2016

Methods of Cancer Treatment, Summary

Methods of Cancer Treatment - Summary

So far, we have discussed a number of cancer treatment methods, conventional and novel methods.  Each method has its own advantages and disadvantages.  Although significant progresses have been made in some of them in recent years, it seems like there is no perfect way to treat cancer at the present time.  Why? 

Remember that most cancer cells are mutated and transformed from normal/stem cells through problematic mutations; the problematic mutations could be only one out of many thousands of mutations.  Thus cancer cells are just like brothers/sisters of normal cells and similar in many ways.  This is what makes it so difficult to treat cancer.  In addition, any treatment that contravenes the growth of cancer cells might also affect normal cells, thus resulting in side effects.  Fortunately, modern technologies in surgery, chemotherapy, and radiotherapy have made significant progresses in reducing the side effects (i.e., injuries of normal cells).  

If there is a perfect way and it’s easy to deal with, we wouldn’t have many thousands of scientists in the world working day and night on finding better answers.  The way the world is created by nature, we are going to have a difficult time to find a perfect way to treat cancer.  However, researchers are making progress inch by inch; newer and better methods have been developed in the last 50 years or so and there will be more and more improvements discovered in the coming years to fight against cancer.

In my opinion, stem cell related therapies have the best chance to be among the best methods for treating cancer.  Among them, two strategies are most appealing to me; they are (1) potential treatment by exosomes, and (2) reversing cancer cells back to normal cells.  However, a lot of technical hurdles must be overcome before either can become practical.  In any case, I believe this is an exciting period of time for the research and development of cancer treatment. We are also putting some of our efforts in this general area and hope to make some contributions. 

Although there may not be a perfect therapy for cancer treatment at the present time, there are a few good ways to reduce the risk of getting cancer and/or to slow down cancer growth.  Other than the methods described previously, there are other aspects to consider in order to reduce the chances of getting cancer.  We will talk about these later. 

© Jiajiu Shaw, 2016

Disclaimer: This blog is written solely for informational purposes. It does not constitute the practice of any medical, nursing or other medical professional health care advice, diagnosis, or treatment. Although some commercial products, publications, and services are mentioned in this blog, the author does not endorse any specific products, publications, or services.  None of the contents in this blog represents or warrants that any of the products, publications, or services is appropriate or effective for their intended purposes. Readers shall always seek the advice of their physicians or other medical practitioners with any questions regarding personal health or medical conditions and shall be solely responsible for their own decisions and/or actions.